Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFÎºB and AhR and EGFR-ERK pathway

Article ID	Journal	Published Year	Pages	File Type
5846843	Toxicology and Applied Pharmacology	2011	12 Pages	PDF

Abstract

âº Effects of plant polyphenols on inflammatory responses in human keratinocytes. âº Inflammatory stimuli used: TGFalpha, TNFalpha+IFNgamma, UVA+UVB, and LPS. âº Inflammatory pathways connected with NFï«B, ERK1/2, EGFR, and AhR were investigated. âº Plant polyphenols, flavonoids, stilbenoids, and phenylpropanoids, were studied. âº Modulation of inflammation depends on phenolic core structure and glycosylation.

Keywords

EGFR AHR Cytokines Plant polyphenols Keratinocytes

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

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Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFÎºB and AhR and EGFR-ERK pathway

Authors

Alla I. Potapovich, Daniela Lulli, Paolo Fidanza, Vladimir A. Kostyuk, Chiara De Luca, Saveria Pastore, Liudmila G. Korkina,