| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846851 | Toxicology and Applied Pharmacology | 2011 | 9 Pages |
Abstract
⺠Exposed ApoE knockout mice (30-week) to diesel exhaust (DE) for 7 weeks. ⺠Examine iNOS expression and activity in the blood vessels and heart. ⺠DE exposure enhanced iNOS protein and mRNA expression in the aorta and heart. ⺠iNOS activity was also increased after DE exposure. ⺠This up-regulation of iNOS may contribute to vascular dysfunction and atherogenesis.
Keywords
iNOSTNFApoE knockout micehypoxanthine phosphoribosyltransferase-1HPRT1oxLDLGM-CSFRT-PCRMIPNF-κBPM10IL-1ROSAtherosclerosisdiesel exhaustinterleukin-1Enzyme-linked immunosorbent assayELISAinducible nitric oxide synthasegranulocyte-macrophage colony-stimulating factortumor necrosis factorNuclear factor-kappa Bphenylephrinecarbon monoxidenitrotyrosineNitric oxidemacrophage inflammatory proteinReactive oxidative species
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Authors
Ni Bai, Takashi Kido, Terrance J. Kavanagh, Joel D. Kaufman, Michael E. Rosenfeld, Cornelis van Breemen, Stephan F. van Eeden,