| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846906 | Toxicology and Applied Pharmacology | 2011 | 8 Pages |
Abstract
⺠These studies analyze macrophage activation by mediators released from acetaminophen-damaged hepatocytes. ⺠Factors released from acetaminophen-injured hepatocytes induce macrophage ROS production and expression of COX-2, chemokines, and RAGE. ⺠Hepatocyte-mediated macrophage activation involves p44/42 MAP kinase signaling. ⺠HMGB1 is released from acetaminophen-injured hepatocytes and contributes to macrophage activation.
Keywords
DTPAHMGB1Heme oxygenase-1NAPQICM-H2DCFDAHO-1EGTAHEPESMIPHigh-mobility group box1COXLPS4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acidMTTcyclooxygenaseEthyl pyruvateethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acidAcetaminophendiethylene triamine pentaacetic acidLOXlipoxygenaselipopolysaccharidemethylthiazolyldiphenyl-tetrazolium bromidemacrophage inflammatory proteinmitogen activated protein kinaseMAP kinase
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Authors
Ana-Cristina Dragomir, Jeffrey D. Laskin, Debra L. Laskin,