| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846907 | Toxicology and Applied Pharmacology | 2011 | 10 Pages |
Abstract
⺠Tungsten-alloy caused H3-Ser10 dephosphorylation in C2C12 and hippocampal primary cultures. ⺠Dramatic H3-Ser10 dephosphorylation was found in all cobalt treated cultures. ⺠C2C12 cultures exposed to tungsten-alloy or cobalt exhibited decrease in H3 pan-acetylation. ⺠Tungsten-alloy and cobalt mediated H3-Ser10 dephosphorylation was reversed with BAPTA-AM. ⺠These epigenetic modifications were mediated by changes in calcium homeostasis and buffering.
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Authors
Ranjana Verma, Xiufen Xu, Manoj K. Jaiswal, Cara Olsen, David Mears, Giuseppina Caretti, Zygmunt Galdzicki,