| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846913 | Toxicology and Applied Pharmacology | 2011 | 9 Pages |
Abstract
⺠We examine the roles of zebrafish CYP1C1 and CYP1C2 in TCDD developmental toxicity. ⺠TCDD induces mRNA expression of both CYP1Cs in the mesencephalic vein. ⺠Knockdown of each CYP1C prevents mesencephalic circulation failure by TCDD. ⺠Induced CYP1Cs are involved in reduction of mesencephalic vein blood flow by TCDD.
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Authors
Akira Kubota, John J. Stegeman, Bruce R. Woodin, Toshihiko Iwanaga, Ryo Harano, Richard E. Peterson, Takeo Hiraga, Hiroki Teraoka,