| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846918 | Toxicology and Applied Pharmacology | 2011 | 12 Pages |
Abstract
⺠Strategy for PLGA nano-encapsulation of a bioactive synthetic coumarin, 4 methyl 7 hydroxy coumarin (SC) is formulated. ⺠Anti-cancer potentials of nano-encapsulated SC (NC) are evaluated in skin papilloma cells A375 through standard protocols. ⺠Data of CD and Tm indicate concentration dependent interactions of NC bringing conformational changes in target DNA. ⺠Particle size of NC and physico-chemical interactions with target DNA show NC as a more potent anti-cancer drug than SC. ⺠NC has less cytotoxic effects, and can cross the blood brain barrier - important features for strategic drug design.
Keywords
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Authors
Soumya Sundar Bhattacharyya, Saili Paul, Arnab De, Durba Das, Asmita Samadder, Naoual Boujedaini, Anisur Rahman Khuda-Bukhsh,