| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5846921 | Toxicology and Applied Pharmacology | 2011 | 8 Pages |
Abstract
⺠We addressed the involvement of mitochondria in guttiferone (GA) toxicity toward cancer cells. ⺠GA promoted membrane permeabilization, membrane potential dissipation, NAD(P)H depletion, ROS accumulation and ATP depletion. ⺠These actions could be implicated in the well-documented anti-cancer property of GA/structure related compounds.
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Authors
Gilberto L. Pardo-Andreu, Yanier Nuñez-Figueredo, Valeria G. Tudella, Osmany Cuesta-Rubio, Fernando P. Rodrigues, Cezar R. Pestana, Sérgio A. Uyemura, Andreia M. Leopoldino, Luciane C. Alberici, Carlos Curti,