| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5847082 | Trends in Pharmacological Sciences | 2011 | 5 Pages |
Abstract
Gastrin, acting through peripheral cholecystokinin (CCK) 2 receptors, is a major hormonal regulator of gastric acid secretion. The effects of gastrin on acid secretion occur both acutely and chronically because gastrin directly stimulates gastric acid secretion and also exerts trophic effects on the enterochromaffin-like and parietal cells that together constitute the acid secretory apparatus of the stomach. Several antagonists that target the CCK2 receptor have been identified and investigated for the treatment of gastroesophageal reflux disease and pancreatic cancer. In this paper, we discuss the contribution of gastrin to these disease pathologies and the data generated to date from clinical studies investigating CCK2 receptor antagonists.
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Authors
Magda Morton, Clodagh Prendergast, Terrance D. Barrett,