| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5847742 | Chemico-Biological Interactions | 2015 | 8 Pages |
Abstract
It is identified that myristicin is a mechanism-based inhibitor of CYP1A2 through CYP cocktail screening, IC50 shift calculation and GSH capturing assays in HLMs. And the reactive metabolites were identified as a quinone and its tautomer through detailed analysis the cleavage processes of metabolites and GSH-myristicin adduct in phase I metabolism assays using UPLC-MS2.
Keywords
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Authors
Ai-Hong Yang, Xin He, Jun-Xiu Chen, Li-Na He, Chun-Huan Jin, Li-Li Wang, Fang-Liang Zhang, Li-Jun An,