Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5848109 | Chemico-Biological Interactions | 2013 | 9 Pages |
Abstract
Mangiferin, a polyphenol compound of C-glucoside, is well-known for its anti-inflammatory, antioxidant, anticancer, antidiabetic and cognitive enhancement properties. In this study, we investigated the neuroprotective effect of mangiferin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD), which is most popular and widely used to evaluate therapeutic implications of new protective agents. Male C57BL/6 mice were orally treated with mangiferin (10, 20 and 40Â mg/kg body wt.) for 14Â days and from 10th day onwards MPTP (30Â mg/kg, i.p.) was injected for last 5Â days. MPTP treatment leads to enhanced oxidative stress, induction of apoptosis (upregulates the expression of Bax, proapoptotic protein and downregulates the expression of anti-apoptotic marker Bcl-2), and loss of dopominergic neurons which results in motor impairments. Results of our study confirmed that mangiferin prevented MPTP-induced behavioral deficits, oxidative stress, apoptosis, dopaminergic neuronal degeneration and dopamine depletion. Taken together, we conclude that mangiferin attenuates the dopaminergic neurodegeneration mainly through its potent antioxidant and antiapoptotic properties.
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Authors
Mani Kavitha, Jagatheesan Nataraj, Musthafa Mohammed Essa, Mushtaq A. Memon, Thamilarasan Manivasagam,