| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848160 | Chemico-Biological Interactions | 2013 | 9 Pages |
Abstract
DZN induced histophatological damages and elevated the level of cardiac marker CK-MB. These effects were associated with increased MDA level, lower level of reduced GSH and induction of apoptosis through elevation of Bax/Bcl2 ratio (both protein and mRNA levels), cytochrome c release to the cytosol and activation caspase 3 in cardiac tissue. Crocin (25 and 50Â mg/kg) or vitamin E improved histopathological damages, decreased MDA and CK-MB, increased GSH content and attenuated the increase of Bax/Bcl2 ratio, activation of caspase 3 and release of cytochrome c to the cytosol induced by DZN. In summary, DZN induced mitochondrial-mediated apoptosis in heart tissue of rat following subchronic exposure. Crocin, as an antioxidant, showed protective effects against DZN cardiotoxicity by reducing lipid peroxidation and alleviating apoptosis.
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Authors
Bibi Marjan Razavi, Hossein Hosseinzadeh, Ahmad Reza Movassaghi, Mohsen Imenshahidi, Khalil Abnous,