| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848223 | Chemico-Biological Interactions | 2013 | 7 Pages |
Abstract
⺠H2O2 inhibits the mitochondrial carnitine/acylcarnitine transporter. ⺠Only mutants containing C136 and C155 were inactivated and inhibition was reverted by DTE. ⺠H2O2 reacts with C136 and C155 and inactivates the transporter by forming a disulphide. ⺠Inhibition by H2O2 could play a regulatory role of the mitochondrial Ã-oxidation.
Keywords
dithioerythritolcACTHEPESANCN-acetyl-l-cysteineN-ethylmaleimideNACDTEMTSCys1,4-piperazinediethanesulfonic acid4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidl-CysteineROSβ-oxidationAdenine nucleotide carrierPipesLiposomesMethanethiosulfonateMitochondriaNEMwild-typeCarnitinecarnitine/acylcarnitine translocase
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Authors
Annamaria Tonazzi, Lara Console, Cesare Indiveri,