| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848246 | Chemico-Biological Interactions | 2012 | 10 Pages |
Abstract
⺠Glycyrrhizin markedly increase in both CYP3A4 mRNA and protein levels. ⺠The transcriptional activation of CYP3A4 through glycyrrhizin is PXR-dependent. ⺠Glycyrrhizin activates the DNA-binding capacity of the PXR. ⺠Glycyrrhizin can protect the liver tissue from the LCA-induced hepatotoxicity.
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Authors
Yu-Guang Wang, Jian-Ming Zhou, Zeng-Chun Ma, Hua Li, Qian-De Liang, Hong-Ling Tan, Cheng-Rong Xiao, Bo-Li Zhang, Yue Gao,