| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848260 | Chemico-Biological Interactions | 2013 | 5 Pages |
Abstract
⺠Molecules designed to realkylate aged cholinesterases are proposed. ⺠Their X-ray structure in complex with aged butyrylcholinesterase was solved. ⺠The structures show an orientation of the molecules incompatible with realkylation. ⺠Better designs based on the X-ray structures are proposed.
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Authors
Marielle Wandhammer, Martijn de Koning, Marco van Grol, Mélanie Loiodice, Laura Saurel, Daan Noort, Maurice Goeldner, Florian Nachon,