| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848331 | Chemico-Biological Interactions | 2013 | 5 Pages |
Abstract
⺠Human PON1 mutants were produced to improve OP binding at lower concentrations. ⺠F347W/H115W GB hydrolysis was achieved by a KM which was nearly half H115W alone. ⺠Stereoselective hydrolysis was improved for the P(-) isomer of GA in variant F347W/H115W. ⺠VX hydrolysis was unaltered by mutations.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Stephen D. Kirby, Joseph R. Norris, J. Richard Smith, Brian J. Bahnson, Douglas M. Cerasoli,