| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848366 | Chemico-Biological Interactions | 2013 | 8 Pages |
Abstract
⺠An in vitro screening protocol for potential toxicity of triaryl phosphates was developed. ⺠Isomers of tert-butyl phenyl phosphate produced the least BChE inhibition in vitro. ⺠BChE inhibition by in vitro bioactivated TAPS correlated with esterase inhibition in vivo. ⺠The flavonoid naringenin reduced bioactivation of TCPs into BChE inhibitor (s).
Keywords
ED50ToCPphenyl valerateTMBPAcylpeptide hydrolaseCBDPRLMsAPHPNVBChERBCsNTEOPIDNbutyrylcholinesteraseTBPBTCEtOHIC50NADPHRed blood cellsdouble-distilled waterAChEEthanolOrganophosphateEsterasesAcetylcholinesteraseCESBiomarkerMUATAPTCPRat liver microsomesneuropathy target esteraseorganophosphate-induced delayed neuropathynicotinamide adenine dinucleotide phosphate reducedParaoxoncarboxylesterase
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Authors
Paul E. Baker, Toby B. Cole, Megan Cartwright, Stephanie M. Suzuki, Kenneth E. Thummel, Yvonne S. Lin, Aila L. Co, Allan E. Rettie, Jerry H. Kim, Clement E. Furlong,