Human aldo-keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells

Article ID	Journal	Published Year	Pages	File Type
5848427	Chemico-Biological Interactions	2012	10 Pages	PDF

Abstract

âº Human AKR7A2 protects cells from the cytotoxicity of some reactive aldehydes. âº Human AKR7A2 also protects cells from DNA damage caused by two of these aldehydes. âº Human AKR7A2 lowers menadione-induced ROS. âº First demonstration that AKR7A2 plays a role in detoxication in cells.

Keywords

2′7′-dichlorodihydrofluorescein diacetate DCFH/DA 4-hydroxynonenal HGPRT HNE AKR SSA IC50 CBA MUC MTT ROS Aldehydes aldo–keto reductase Oxidative stress succinic semialdehyde menadione naphthoquinone hypoxanthine guanine phosphoribosyl transferase Phenanthrenequinone Reactive oxygen species