Article ID Journal Published Year Pages File Type
5848432 Chemico-Biological Interactions 2012 9 Pages PDF
Abstract
► ALDH1A2 and ALDH2 overexpression in two cell lines results in increased cell proliferation and drug resistance. ► Diethylaminobenzaldehyde inhibits both ALDH1A2 and ALDH2. ► The enzymatic activity of both isoenzymes can be detected by Aldefluor flow cytometry assay.
Keywords
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
Preview
The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance
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