| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848445 | Chemico-Biological Interactions | 2012 | 7 Pages |
Abstract
⺠Reverse bacterial mutagenicity of GW9662 was due to its nitroreduction by bacteria. ⺠GW9662 had rapid clearance and large volume of distribution in i.v. dosed rats. ⺠Parent drug was virtually absent in plasma from orally dosed rats and dogs. ⺠Amine metabolite was the major species found in plasma on oral animal dosing. ⺠This amine metabolite was absent in plasma following animal intravenous dosing.
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Authors
Izet M. Kapetanovic, Alexander V. Lyubimov, Elena V. Kabirova, Kasim K. Kabirov, Laura Rasay, Robert Swezey, Carol Green, Levy Kopelovich,