| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848446 | Chemico-Biological Interactions | 2012 | 8 Pages |
Abstract
⺠Pycnidione was first isolated from fungal Theissenia rogersii 92031201. ⺠Pycnidione markedly and selectively inhibited lung A549 cancer cell proliferation. ⺠The G1 phase cell cycle arrest and apoptosis were induced by pycnidione. ⺠The levels of cyclins and survivin were significantly attenuated by pycnidione. ⺠Pycnidione caused ROS formation and disrupted the mitochondrial membrane potential.
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Authors
Che-Jen Hsiao, Shih-Hsin Hsiao, Wei-Lin Chen, Jih-Hwa Guh, George Hsiao, Yen-Ju Chan, Tzong-Huei Lee, Chi-Li Chung,