| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848464 | Chemico-Biological Interactions | 2011 | 10 Pages |
Abstract
⺠Antioxidant enzymes in the apoptotic mechanism induced by apigenin in HepG2 cells. ⺠Catalase downregulation play an essential role in apigenin-induced apoptosis. ⺠Catalase added to the culture medium partially protected apigenin-induced cell death. ⺠Direct involvement of H2O2 in the apoptotic mechanism induced by apigenin. ⺠Apigenin promotes GSH depletion and ROS generation, contributing to apoptosis.
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Authors
Glaucio Valdameri, Marina Trombetta-Lima, Paulo R. Worfel, Amanda R.A. Pires, Glaucia R. Martinez, Guilhermina R. Noleto, Silvia M.S.C. Cadena, Mari C. Sogayar, Sheila M.B. Winnischofer, Maria E.M. Rocha,