| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848472 | Chemico-Biological Interactions | 2012 | 13 Pages |
Abstract
⺠Testing substances are administered intrastriatally to Wistar rats. ⺠Examined vulnerable brain regions: striatum, hippocampus and cortex. ⺠parameters of oxidative status and behavior of the animals were measured/monitored. ⺠Paraquat (PQ) administration triggered oxidative stress and excitotoxicity. ⺠Pre-treatment with glutathione reductase prevented/reduced PQ induced neurotoxicity.
Keywords
LPOMDAHMPSGPXNACi.p.GSSGNADPHGSHN-acetyl-cysteineNO3−O2−Adenosine-triphosphateATPI.S.Nitrosative stressOxidative stressIntraperitoneallySuperoxide anion radicalSODNeurotoxicitySuperoxide dismutasemalondialdehydeNADHNitratenicotinamide adenine dinucleotide phosphateNAD, nicotinamide adenine dinucleotidehexose monophosphate shuntParaquatLipid peroxidationGlutathioneglutathione (oxidized form)glutathione (reduced form)glutathione reductaseglutathione peroxidase
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Authors
Mirjana M. Djukic, Marina D. Jovanovic, Milica Ninkovic, Ivana Stevanovic, Katarina Ilic, Marijana Curcic, Jelena Vekic,