Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5848493 | Chemico-Biological Interactions | 2011 | 10 Pages |
Abstract
This study evaluated the selective effects of 2-isopropyl-3-butyl-8-(4-fluorophenylamino)-3H-imidazo[4,5-g]quinazoline (B-2), a member of a series of quinazolines, on the cell survival and growth of the non-small cell lung cancer (NSCLC) cell line A549 in vitro and in vivo. Cytotoxicity assay, hollow fiber assay and cell xenograft model experiment revealed that B-2 showed selective effects on A549 cell survival or growth in a dose-dependent manner. At a dose of 100Â mg/kg, B-2 showed stronger efficacy on tumor growth inhibition in nude mice than Iressa. Exposure of A549 cells to B-2 caused inhibition of EGFR-dependent ERK-MAPK activation. In addition, inhibition of cell cycle progression and induction of mitochondria-dependent apoptosis might contribute to present the multitarget pathway of non-small cell lung cancer treatment of B-2.
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Authors
Zhe Chen, Xin Huang, Hongyu Yang, Wenbo Ding, Lingyan Gao, Ziqi Ye, Yandong Zhang, Yongping Yu, Yijia Lou,