| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848507 | Chemico-Biological Interactions | 2012 | 9 Pages |
Abstract
⺠Induction of CYP3A by SBP and its main components is investigated. ⺠SBP increases the activity, mRNA and protein expressions of CYP3A4 in HepG2 cells. ⺠SBP enhances the activities and mRNA expressions of CYP3A1 and CYP3A2 in rats. ⺠Bufalin, cinobufagin, and resibufogenin are identified as novel CYP3A4 inducers. ⺠Bufalin and cinobufagin play a critical role in CYP3A4 induction effects of SBP.
Keywords
HLMCytochrome P450 3AMDZGRFGRERESBorneolDDIBUFTCMresibufogeninGinsenoside Rg1P450MUSGinsenoside ReCHDCYP3A1′-hydroxymidazolamPBSTESSBPSDSDEXginsenoside RfDMSOLC–MS/MSMTTInductionBORBufalinCoronary heart diseasestestosteronedrug–drug interactionCinDexamethasoneDimethyl sulfoxideRifampicinsodium dodecyl sulfateCytochrome P450CinnamaldehydeCinobufagintraditional Chinese medicineShexiang Baoxin PillPhosphate-buffered salineMusconeMidazolamhuman liver microsomepolymerase chain reactionPCRRifliquid chromatography–tandem mass spectrometry
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Bo Jiang, Fei Cai, Shouhong Gao, Liyuan Meng, Fengying Liang, Xiao Dai, Wen Xu, Wansheng Chen,