Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5848521 | Chemico-Biological Interactions | 2011 | 7 Pages |
Abstract
⺠Antitumor effects of a novel benzonaphthofurandione (8e) on colorectal cancer HCT 116 cells both in vitro and an in vivo. ⺠The anti-proliferative activity of 8e was associated with the induction of cell cycle arrest in the G0/G1 phase. ⺠The 8e-induced cell cycle arrest was well correlated with the suppression of CDK2, CDK4, cyclin D1, cyclin E, c-Myc, and pRb. ⺠The tumor growth in xenograft nude mice by 8e (10 mg/kg) significantly inhibited without any overt toxicity. ⺠The down-regulation of EGFR, Akt, and mTOR signalings were associated with the anti-proliferative activity of compound 8e.
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Authors
Hwa-Jin Chung, Hee-Kyung Rhee, Sang Kook Lee, Hea-Young Park Choo,