| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5848571 | Environmental Toxicology and Pharmacology | 2016 | 8 Pages |
â¢The values of LC50 (24, 48, 72 and 96 h) of imidacloprid were 167.7, 158.6, 147.9 and 145.8 mg/L, respectively, safety concentration was 42.55 mg/L. The erythrocyte micronuclei assays and the comet assay results showed that imidacloprid has genetic toxic effect on the loach erythrocytes.â¢To assess the physiological and biochemical damage by imidacloprid, the activity values of hepatic glutamic-pyruvic transaminase (GPT) and glutamic-oxalacetic transaminase (GOT) declined in treatment groups.â¢Histological examination of testis revealed that imidacloprid treatment resulted in disorganized lobules and cysts structures.â¢In the present work, we also investigated the joint toxicity of pesticides commonly used in paddy fields (imidacloprid and lambda-cyhalothrin) on Misgurnus anguillicaudatus, and confirmed that a synergistic effect existing in the binary mixtures.
The present investigation was aimed to assess the effects of imidacloprid on the survival, genetic materials, hepatic transaminase activity and histopathology of loach (Misgurnus anguillicaudatus). The values of LC50 (24, 48, 72 and 96Â h) of imidacloprid were 167.7, 158.6, 147.9 and 145.8Â mg/L, respectively, and the safety concentration was 42.55Â mg/L. The erythrocyte micronuclei assays and the comet assay results showed that imidacloprid had genetic toxic effect on the loach erythrocytes. To assess the physiological and biochemical damage caused by imidacloprid, the activities of hepatic glutamic-pyruvic transaminase (GPT) and glutamic-oxalacetic transaminase (GOT) were measured and their values declined in treatment groups. Histological examination of testis revealed that imidacloprid treatment resulted in disorganized lobules and cysts structures. In the present work, we also investigated the joint toxicity of pesticides commonly used in paddy fields (imidacloprid and lambda-cyhalothrin) on M. anguillicaudatus, and confirmed that a synergistic effect existing in the binary mixtures. The results of our study provide relevant and comparable toxicity information that are useful for safety application of pesticides.
