Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5848717 | Environmental Toxicology and Pharmacology | 2015 | 8 Pages |
Abstract
Polychlorinated biphenyls (PCBs) are proved endocrine disrupting potentials. Reference points (RP) for PCBs are derived from dose-response relationship analysis by using the traditional no observed adverse effect or lowest observed adverse effect level (NOAEL/LOAEL) methods, or a more advanced benchmark dose (BMD) method. In present study, toxicological RP for PCBs' thyroid disruption was established and compared between NOAEL/LOAEL and BMD method in an ovariectomized (OVX) rat model. Sham and OVX controls were given corn oil while other OVX groups were administered with 0.1, 1.0, 5.0, and 10.0 mg/kg bw of PCBs (aroclor 1254) respectively by gavage. Body weight change, liver type I 5â²-deiodinase (5â²-DI) activity, serum total thyroxine (tT4), triiodothyroxine (tT3), thyroid stimulating hormones (TSH), and thyroid histopathological changes were measured and analyzed. In PCBs-treated groups, serum tT4, tT3, TSH, and histopathological examinations showed significant changes with a dose-dependent manner compared with those in OVX control (P < 0.05). The toxicological RP for PCBs affecting thyroid function of OVX rats was 0.02 mg/kgâ²bw based on BMD analysis.
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Authors
Hao Chen, Xiaopeng Zhang, Xudong Jia, Qian Li, Qing Su, Wei Wang, Zhaoping Liu,