Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5848898 | Environmental Toxicology and Pharmacology | 2013 | 7 Pages |
Abstract
The aim of our study was to examine the effect of calorie restriction (CR) on oxidative and nitrosative liver injury in rats, induced by acute ethanol intoxication. Male Wistar rats were divided into groups: (1) control; (2) calorie-restricted groups with intake of 60-70% (CR60-70) and 40-50% of daily energy needs (CR40-50); (3) ethanol-treated group (E); (4) calorie-restricted, ethanol-treated groups (EÂ +Â CR60-70 and EÂ +Â CR40-50). Ethanol was administered in 5 doses of 2Â g/kg every 12Â h, and duration of CR was 5 weeks before ethanol treatment. Malondialdehyde and nitrite and nitrate level were significantly lower in EÂ +Â CR60-70 and higher in EÂ +Â CR40-50 vs. E group. Liver reduced glutathione content and activity of both superoxide dismutase izoenzymes were significantly higher in EÂ +Â CR60-70 and lower in EÂ +Â CR40-50 vs. E group. Oxidative stress may be a potential mechanism of hormetic effects of CR on acute ethanol-induced liver injury.
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Authors
DuÅ¡an MladenoviÄ, Milica NinkoviÄ, Vuk AleksiÄ, Tamara Å ljivanÄanin, Danijela VuÄeviÄ, Vera TodoroviÄ, Milena StankoviÄ, Olivera StanojloviÄ, Tatjana RadosavljeviÄ,