| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5854868 | NeuroToxicology | 2014 | 11 Pages |
Abstract
- MPP+ (20 μM) inhibits the activity of nigral dopamine neurons in brain slices.
- The early phase of inhibition involves DA release and D2 receptor activation.
- The late component of inhibition mainly involves activation of KATP channels.
- The inhibitory effects of MPP+ were not prevented by blocking HCN channels.
- Sustained inhibition of firing likely represents an initial stage in cell death.
Keywords
KATPGIRK1-methyl-4-phenylpyridiniumVTAMPTPTTXaCSFKCaDATSNCVMAT2HCN1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineMPP+ROSAdenosine TriphosphateATPDopamine transportertetrodotoxinsubstantia nigra pars compactahyperpolarization-activated currentDopamineBrain slicelocus coeruleusartificial cerebrospinal fluidvesicular monoamine transporter 2ventral tegmental areaHCN channelsKATP channelsATP-sensitive potassium channelsCalcium-activated potassium channelsReactive oxygen species
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Authors
Andrew G. Yee, Sun-Min Lee, Morag R. Hunter, Michelle Glass, Peter S. Freestone, Janusz Lipski,