| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5855115 | NeuroToxicology | 2013 | 6 Pages |
Abstract
⺠This in vitro study examines the response of isolated dopaminergic neurons and brain striatum cultures (Sprague-Dawley rat) to concentrated air pollutants (CAPs). ⺠Evidence of particle-size dependent neurotoxicity is documented in both in vitro systems. ⺠Evidence of oxidative stress damage is collected in both systems. ⺠Neurotoxicity is enhanced in brain striatum cultures relative to isolated neurons exposed to CAPs. ⺠Unlike in vivo models of CAPs Apo â/â neurodegeneration, oxidative stress is not critical to in vitro neurotoxicity.
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Authors
Patricia Gillespie, Julianne Tajuba, Morton Lippmann, Lung-Chi Chen, Bellina Veronesi,