| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5855128 | NeuroToxicology | 2013 | 9 Pages |
Abstract
The ABR thresholds in the 800-5000Â mM groups exceeded the maximum recording limit at 16 and 32Â kHz 1 day after 3-NP administration. The ABR threshold in the 500Â mM 3-NPÂ +Â KRG group was significantly lower than that in the 500Â mM 3-NP group from post 1 week to 1 month. The mean type II fibrocyte counts significantly differed between the control and 3-NP groups and between the 3-NP and 3-NPÂ +Â KRG groups. Spiral ganglion cell degeneration in the 3-NP group was more severe than that in the 3-NPÂ +Â KRG group. This animal model exhibited a dose-dependent hearing loss with histological changes. KRG administration ameliorated the deterioration of hearing by 3-NP.
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Authors
Chunjie Tian, Young Ho Kim, Young Chul Kim, Kyung Tae Park, Seung Won Kim, Youn Ju Kim, Hye Jin Lim, Yun-Hoon Choung,