| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5855212 | NeuroToxicology | 2012 | 10 Pages |
Abstract
⺠We observed differences in DNA damage removal depending on the challenge insult and the differentiation state. ⺠Differentiated MSN cells, compared with undifferentiated cells, showed greater sensitivity to UVC and decreased DNA damage over time. ⺠Undifferentiated cells displayed genotoxicity induced by oxidative insult and tended to accumulate DNA damage and 8OHdG lesions over time. ⺠We suggest the participation of GG-NER, TC-NER and BER proteins in the removal of 8-OHG and CPDs indicating a dynamic role in overall response to damage.
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Authors
P. Ramos-Espinosa, E. Rojas, M. Valverde,