| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5855233 | NeuroToxicology | 2012 | 9 Pages |
Abstract
⺠5 nm ceria were administered to rats in vivo and end points determined 30 days later. ⺠Indices of oxidative stress were determined in three brain regions. ⺠5 nm ceria NP exert pro-oxidant effects in brain without crossing the BBB. ⺠Important cautionary implications of proposed therapeutic use of ceria NP emerged.
Keywords
GPX3NTENMHNEMDLhsp70RNSiNOSEELSCATROSHydrogen peroxideTemOxidative stressSODCeriumNeurotoxicityinducible nitric oxide synthaseSuperoxide dismutaseCeriaEELS, electron energy loss spectroscopyICP-MSinductively coupled plasma mass spectrometryMethod Detection LimitBrainEngineered nanomaterialRatTransmission electron microscopyNanoparticlesNanomaterialH2O2heat shock protein 70Catalaseprotein carbonylglutathione reductaseglutathione peroxidasereactive nitrogen speciesReactive oxygen species
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Sarita S. Hardas, Rukhsana Sultana, Govind Warrier, Mo Dan, Rebecca L. Florence, Peng Wu, Eric A. Grulke, Michael T. Tseng, Jason M. Unrine, Uschi M. Graham, Robert A. Yokel, D. Allan Butterfield,