| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5855259 | NeuroToxicology | 2012 | 6 Pages |
Wistar rats were treated with caffeine or 2-bromoethylamine, the effect of caffeine on the activity of semicarbazide-sensitive amine oxidase (SSAO) in rat serum and tissues was studied using various LC-MS methods. Caffeine was found to present in all tissues after administration for 10 days and accumulated for 25 days. The level of caffeine was high in brain and liver, and the SSAO activity in all tissues was found to be inhibited by caffeine. As the concentration of caffeine increased, the SSAO activity decreased. The inhibition ratio was correlated to the levels of caffeine present. We presume that caffeine may treat with SSAO activity associated diseases.
⺠Caffeine distribute and accumulate in rat adipose, brain and serum. ⺠Caffeine inhibit the SSAO activity in all rat tissues. ⺠Efficiency of caffeine on adipose and aorta was high.
