| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5855317 | NeuroToxicology | 2012 | 7 Pages |
Abstract
⺠We constructed Nav1.6Q3 sodium channels containing the IFM/QQQ mutation. ⺠Nav1.6Q3 channels expressed in Xenopus oocytes exhibited persistent activation. ⺠Opening of Nav1.6Q3 channels enhanced modification by tefluthrin and deltamethrin. ⺠Modification by S-bioallethrin was not affected by channel opening. ⺠These results provide evidence for differential pyrethroid binding to open channels.
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Authors
Samantha J. McCavera, David M. Soderlund,