Article ID Journal Published Year Pages File Type
5855422 NeuroToxicology 2011 9 Pages PDF
Abstract
► Nigella sativa oil inhibited the development of tramadol tolerance and dependence. ► N. sativa oil inhibited tramadol-induced NO overproduction and oxidative stress. ► N. sativa oil maintained the intracellular antioxidant status. ► The oil appears to be an alternative to treat tramadol tolerance and dependence.
Keywords
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
Preview
Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: Role of nitric oxide and oxidative stress
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