| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5855424 | NeuroToxicology | 2011 | 9 Pages |
Abstract
⺠We report effects of low concentrations of methylmercury on spinal motorneuron cultures. ⺠Methylmercury increases intracellular calcium in these cells at low concentrations. ⺠Release of intracellular zinc accompanies this. ⺠Glutamate receptors and voltage-gated calcium channels provide pathways for methylmercury-induced calcium increase. ⺠Voltage gated sodium channels are not a path involved in this effect.
Keywords
N-methyl-d-aspartateω-CTx-GVIAHEPES-buffered saline solutiontetramethyl rhodamine isothiocyanatePC12TRITCVGCCHBSSOD1α-amino-3-hydroxy-5-methylisoxazole-4-propionateEAANMDAIP3TTXAMPAMeHgTPENDMEMEGTAHEPESFITCCNTF6-Cyano-7-nitroquinoxaline-2,3-dioneBDNFDMSODulbecco's modified Eagle Mediuminositol 1,4,5-trisphosphateN-[2-hydroxyethyl]piperazine-N′-[2-ethanesulfonic acid][Ca2+]iω-conotoxin-GVIAexcitatory amino acidethylene glycol tetraacetic acidamyotrophic lateral sclerosisALStetrodotoxinanalysis of varianceANOVADIVDimethyl sulfoxidepheochromocytoma cellssuperoxide dismutase 1CNQXbrain derived neurotrophic factorintracellular Ca2+ concentrationciliary neurotrophic factorfluorescein isothiocyanateFura-2 fluorescenceMethylmercurymotor neuronsChATDivalent cationsvoltage-gated Ca2+ channelscholine acetyltransferaseExcitatory amino acid receptors
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Authors
Gunasekaran Ramanathan, William D. Atchison,