Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5855429 | NeuroToxicology | 2011 | 9 Pages |
Abstract
⺠Alkaloid monocrotalina (MCT) from Crotalaria retusa, is cytotoxic to cortical neurons and astrocytes. ⺠Neuron/glial cell in co-cultures MCT changes the expression of cytoskeletal components of neurons (βIII-tubulin) and astrocytes (GFAP). ⺠MCT-induced GSH depletion and cytotoxicity were reversed when cytochrome P450 enzyme system was inhibited, suggesting involvement of P450 system metabolism on alkaloid's neurotoxicity.
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Authors
Bruno P.S. Pitanga, Victor Diógenes A. Silva, Cleide S. Souza, Huiara A. Junqueira, Breno O.N. Fragomeni, Ravena P. Nascimento, Ana Rita Silva, Maria de Fátima D. Costa, Ramon S. El-Bachá, Silvia L. Costa,