Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5855439 | NeuroToxicology | 2011 | 8 Pages |
Abstract
⺠Among membrane receptors and/or ion channels targeted by insecticides, ionotropic γ-aminobutyric acid receptors (GABARs) are considered as vital complex protein subunits, mediating fast inhibitory transmission in the central nervous system. ⺠They are targeted by several important classes of insecticides, including cyclodienes (e.g. dieldrin) and phenylpyrazoles (e.g. fipronil). ⺠The present study demonstrates that insect GABARs are regulated by PKC and CaMKinase II. ⺠Furthermore, we have shown that inhibition of the PKC pathway decreases the fipronil sensitivity of GABAR subtype in insect neurosecretory cells.
Keywords
resistant to dieldrinGö6983DumPDBupKaDUM neuronsRDLPhorbol-12-myristate-13-acetatePKCKN-62PMATAG یا triacylglycerols InsecticidediacylglycerolDAGphorbol 12,13-dibutyrateFiproniltransient receptor potentialprotein kinase Acalcium/calmodulin-dependent protein kinase IIProtein kinase CGABAterminal abdominal ganglion
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Authors
Laurence Murillo, Alain Hamon, Zeineb Es-Salah-Lamoureux, Valérie Itier, Sophie Quinchard, Bruno Lapied,