| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5855892 | Regulatory Toxicology and Pharmacology | 2016 | 15 Pages |
Abstract
The lack of adverse effects from acute and subacute dosing suggest that the CMICE-013 injection solution has a reasonable safety margin within the designed concentration range to be utilized in imaging applications. The dosage level of 5 μg/kg was considered the no adverse effect level for both rats and minipigs based on our acute and subacute studies.
Keywords
RBCMCVMCHCCREAPLTMCHphosNOAELALTRDWHCTMPIWBCALBLUCAPTTno adverse effect levelCHOLHDWNOELA/GASTAspartate aminotransferaseAlanine aminotransferaseAlbuminALPEosinophilsbasophilsBASOtrigTriglyceridesMyocardial perfusion imagingMean corpuscular volumeReticulocytesactivated partial thromboplastin timeprothrombin timeSodiumlarge unstained cellsRed cell distribution widthEOsAlkaline phosphatisePhosphorusLymphLymphocytesmean corpuscular hemoglobinmonoMonocytesMean corpuscular hemoglobin concentrationalbumin/globulin ratioNeutNeutrophilshematocritHemoglobinHgbNo observed effect levelPotassiumPlateletscreatinineglobtotal proteinChlorideCalciumred blood cellwhite blood cellsGlobulinGlucGlucose
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Authors
Yin Duan, Xuxu Yan, Lihui Wei, Corinne Bensimon, Pasan Fernando, Terrence D. Ruddy,