Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitization potency. Part 1. Underlying physical organic chemistry principles and the extent to which they are represented in the LLNA validation dataset

- Chemical mechanisms of skin sensitization are reviewed.
- In vivo test methods including the LLNA are discussed.
- Ranges of key physico-chemical parameters are extracted to characterise one type of applicability domain for the LLNA.