Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5856726 | Regulatory Toxicology and Pharmacology | 2015 | 9 Pages |
Abstract
We developed a simple tool for ranking chemical hazard-food pairs to assist policy makers and risk managers selecting the hazard-food pairs that deserve more attention and need to be monitored during food safety inspections. The tool is based on the derivation of a “Priority Index” (PI) that results from the ratio of the potency of the hazard and the consumer exposure. The potency corresponds to a toxicity reference value of the hazard, whereas the exposure results from the combination of the concentration of the hazard in the food, and the food consumption. Tool's assumptions and limitations are demonstrated and discussed by ranking a dataset of 13 mycotoxins in 26 food items routinely analyzed in Switzerland. The presented ranking of mycotoxin-food pairs has to be considered as relative due to scarce exposure data availability, and uncertainties in toxicity reference values. However, this representative example allows demonstrating the simplicity and the ability of the PI tool to prioritize chemical hazard-food pairs.
Keywords
AFG1FB1FB2ZEAOTABMDAFB2DeoxynivalenolAFG2Aflatoxin G2DALYLO(A)ELNO(A)ELQALYBMDLAFB1ADIAflatoxin B1Aflatoxin B2Aflatoxin G1ToolTenuazonic acidPrioritizationOchratoxin AFood safetyHazardAcceptable daily intakebenchmark doseDONRankingZearalenonequality-adjusted life yeardisability-adjusted life yearFumonisin B1Fumonisin B2Risk managementMycotoxinno observed (adverse) effect levelTEA
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Authors
Alessia Stornetta, Barbara E. Engeli, Jürg A. Zarn, Gérard Gremaud, Shana J. Sturla,