Changes in levels of biomarkers of exposure and biological effect in a controlled study of smokers switched from conventional cigarettes to reduced-toxicant-prototype cigarettes

Article ID	Journal	Published Year	Pages	File Type
5856728	Regulatory Toxicology and Pharmacology	2015	19 Pages	PDF

Abstract

Despite increased cigarette consumption, reductions in BoE and BoED were detectable.

Keywords

MLE hsCRP LTB4 PrEP NaB oxLDL NNK IOM BDL 8-OHdG MCP-1 NNN LIP NAT 3-HPMA PAH AFR RTP N-nitrosoanatabine CEMA N-nitrosonornicotine HDL FDA 3-hydroxypropylmercapturic acid MRTP NFDPM GPX 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 8-hydroxydeoxyguanosine cpd Oxidised LDL ISO HAC blq BoE Biomarker of exposure World Health Organisation International Organisation for Standardisation Food and Drug Administration SOD Superoxide dismutase cigarettes per day Smoking EOs mouth level exposure Leukotriene B4 high density lipoprotein low density lipoprotein LDL below detection limit Modified risk tobacco product Institute of Medicine soluble intercellular adhesion molecule Polycyclic aromatic hydrocarbons end of study monocyte chemotactic protein 1 high sensitivity C-reactive protein WHO glutathione peroxidase

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

Changes in levels of biomarkers of exposure and biological effect in a controlled study of smokers switched from conventional cigarettes to reduced-toxicant-prototype cigarettes

Authors

Christopher J. Shepperd, Nik Newland, Alison Eldridge, Linsey Haswell, Frazer Lowe, Ermioni Papadopoulou, Oscar Camacho, Christopher J. Proctor, Don Graff, Ingo Meyer,