| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5856817 | Regulatory Toxicology and Pharmacology | 2013 | 13 Pages |
Abstract
- Development of an Integrated Testing Strategy (ITS) for repeated-dose toxicity.
- Evaluation whether in vivo non-guideline studies are reliable or new testing is recommended.
- Three aspects are assessed: the documentation of the study, the quality of the study design and the scope of examination.
- Proposed non-testing methods: category approach, read across and TTC concept.
Related Topics
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Environmental Science
Health, Toxicology and Mutagenesis
Authors
Inga Tluczkiewicz, Monika Batke, Dinant Kroese, Harrie Buist, Tom Aldenberg, Eduard Pauné, Helvi Grimm, Ralph Kühne, Gerrit Schüürmann, Inge Mangelsdorf, Sylvia E. Escher,