Reduced exposure evaluation of an Electrically Heated Cigarette Smoking System. Part 8: Nicotine bridging - Estimating smoke constituent exposure by their relationships to both nicotine levels in mainstream cigarette smoke and in smokers

► Concept and examples of 'nicotine bridging' are presented. ► Nicotine uptake distribution model estimates exposure to other smoke constituents. ► Model estimates exposure to smoke constituents lacking biomarkers of exposure. ► Clinical study nicotine uptake distributions reflect population nicotine exposure.