| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857130 | Regulatory Toxicology and Pharmacology | 2012 | 9 Pages |
Abstract
⺠γ-Glutamylcysteine (GGC) is a potential therapy for chronic glutathione depletion. ⺠The safety of GGC sodium salt was tested according to OECD toxicology protocols. ⺠GGC sodium salt was not acutely toxic in Wistar rats at 2000 mg/kg body weight. ⺠GGC sodium salt had a NOAEL of at least 1000 mg/kg/day for repeated oral dose. ⺠GGC sodium salt should be considered suitable for GRAS status.
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Authors
S.D. Chandler, M.H. Zarka, S.N. Vinaya Babu, Y.S. Suhas, K.R. Raghunatha Reddy, W.J. Bridge,