| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857131 | Regulatory Toxicology and Pharmacology | 2012 | 9 Pages |
Abstract
⺠We propose a method for analysis of mortality in long-term carcinogenicity bioassays. ⺠Williams-type hazard ratios or survival time ratios are used as effect size. ⺠We develop simultaneous confidence intervals for the hazard ratios. ⺠The intervals can be interpreted in terms of significance and biological relevance. ⺠An extension of the approach allows the pooled analysis over sex and strains.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Esther Herberich, Ludwig A. Hothorn,