| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857163 | Regulatory Toxicology and Pharmacology | 2012 | 12 Pages |
Abstract
⺠Endocrine disruption criteria combining regulatory toxicity and mechanistic studies. ⺠These combined adverse effects with mode of action of toxicity. ⺠Refinement to discriminate endocrine disrupting chemicals of low and higher concern. ⺠For human health specificity and potency to induce endocrine toxicity is considered. ⺠For ecotoxicology further population relevance and negligible exposure is proposed.
Keywords
ECETOCCLPNOAELLOAELMOACRDNOECIPCsACRTDIBFRAdversityInternational Programme on Chemical SafetyPotencyRegistration, Evaluation, Authorisation and Restriction of ChemicalsMargin of exposureMode of actionHuman relevanceREACHWorld Health OrganisationClassification, Labelling and PackagingNo observed effect concentrationEU legislationendocrine disruptorEuropean Centre for Ecotoxicology and Toxicology of ChemicalsTolerable daily intakeAcute-to-chronic ratioNo observed adverse effect levelMOEWeight-of-evidenceSpecificityLowest observed adverse effect levelWHO
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Authors
Remi Bars, Ivana Fegert, Melanie Gross, Dick Lewis, Lennart Weltje, Arnd Weyers, James R. Wheeler, Malyka Galay-Burgos,