| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857224 | Regulatory Toxicology and Pharmacology | 2014 | 8 Pages |
Abstract
- Refine use of non-human primates and current experience on the use of minipigs.
- Tissue distribution studies to support PKPD assessment.
- Mechanisms of nonspecific toxicity of ADCs and ways to increase safety margins.
- Significant adverse effects of biologics cannot necessarily always predicted.
- Specifics of noncanonical mAbs like bispecifics and nanobodies.
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Authors
Andreas Baumann, Kelly Flagella, Roy Forster, Lolke de Haan, Sven Kronenberg, Mathias Locher, Wolfgang F. Richter, Frank-Peter Theil, Marque Todd,