| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857235 | Regulatory Toxicology and Pharmacology | 2012 | 13 Pages |
Abstract
⺠Guiding principles for non-animal skin sensitisation assessment of cosmetics. ⺠Analysis to what extent such an assessment can be made without animal data. ⺠Conclusion that the murine local lymph node assay is not yet dispensable. ⺠Recognition of potency information from alternative tools as the key research area.
Keywords
hMTAcceptable Exposure LevelAELHRIPTWOECOLIPAQRALLNAh-CLATMUSSTDPRASAFCIRDSTCeleC3APCSCCsACDTSCTTCOECD(Q)SARhuman cell line activation testLocal lymph node assayDirect Peptide Reactivity AssayThreshold of toxicological concernAntigen presenting cellsSafety assessmentQuantitative risk assessmentHuman Repeated Insult Patch Testhigh production volumeSkin sensitisationACD, Allergic contact dermatitistest guidelineAlternative methodsSMARTSOrganisation for Economic Co-operation and DevelopmentDendritic cellsLangerhans cellsoctanol–water partition coefficientCosmeticsNESILHERAWeight-of-evidenceHPVKeratinocytes
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Authors
Carsten Goebel, Pierre Aeby, Nadège Ade, Nathalie Alépée, Aynur Aptula, Daisuke Araki, Eric Dufour, Nicola Gilmour, Jalila Hibatallah, Detlef Keller, Petra Kern, Annette Kirst, Monique Marrec-Fairley, Gavin Maxwell, Joanna Rowland, Bob Safford,